Publications

2015

Mutvei AP, Fredlund E, Lendahl U. Frequency and distribution of Notch mutations in tumor cell lines. BMC Cancer. 2015 Apr 25;15(1):311. [Epub ahead of print] PubMed PMID: 25907971.

2014

Henshall TL, Keller A, He L, Johansson BR, Wallgard E, Raschperger E, Mäe MA, Jin S, Betsholtz C, Lendahl U. Notch3 is necessary for blood vessel integrity in the central nervous system. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):409-20. doi: 10.1161/ATVBAHA.114.304849. Epub 2014 Dec 4. PubMed PMID: 25477343.

Georgievska B, Gustavsson S, Lundkvist J, Neelissen J, Eketjäll S, Ramberg V, Bueters T, Agerman K, Juréus A, Svensson S, Berg S, Fälting J, Lendahl U. Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS. J Neurochem. 2014 Aug 25. doi: 10.1111/jnc.12937. [Epub ahead of print] PubMed PMID: 25156639.

Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C. PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res. 2014 Apr;24(4):433-50. doi: 10.1038/cr.2014.34. Epub 2014 Mar 25. PubMed PMID: 24662486

Main H, Radenkovic J, Kosobrodova E, McKenzie D, Bilek M, Lendahl U. Cell surface antigen profiling using a novel type of antibody array immobilised to plasma ion-implanted polycarbonate. Cell Mol Life Sci. 2014 Oct;71(19):3841-57. doi: 10.1007/s00018-014-1595-2. Epub 2014 Mar 13. PubMed PMID: 24623559.

Andersson ER, Lendahl U. Therapeutic modulation of Notch signalling–are we there yet? Nat Rev Drug Discov. 2014 May;13(5):357-78. doi: 10.1038/nrd4252. Review. PubMed PMID: 24781550

2013

Olsson F, Schmidt S, Althoff V, Munter LM, Jin S, Rosqvist S, Lendahl U, Multhaup G, Lundkvist J. Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions. J Biol Chem. 2014 Jan 17;289(3):1540-50. doi: 10.1074/jbc.M113.498246. Epub 2013 Nov 13. PubMed PMID:24225948; PubMed Central PMCID: PMC3894335.

Liu T, Yu R, Jin SB, Han L, Lendahl U, Zhao J, Nistér M. The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics. Exp Cell Res. 2013 Nov 1;319(18):2893-904. doi:10.1016/j.yexcr.2013.07.010. Epub 2013 Jul 20. PubMed PMID: 23880462.

Main H, Radenkovic J, Jin SB, Lendahl U, Andersson ER. Notch signaling maintains neural rosette polarity. PLoS One. 2013 May 10;8(5):e62959. doi:10.1371/journal.pone.0062959. Print 2013. PubMed PMID: 23675446; PubMed Central PMCID: PMC3651093.

Lanner F, Lee KL, Ortega GC, Sohl M, Li X, Jin S, Hansson EM, Claesson-Welsh L, Poellinger L, Lendahl U, Farnebo F. Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling. Stem Cells Dev. 2013 May 1;22(9):1360-9. doi: 10.1089/scd.2012.0259. Epub 2013 Feb 12. PubMed PMID:23379656.

Hansson EM, Lendahl U. Regenerative medicine for the treatment of heart disease. J Intern Med. 2013 Mar;273(3):235-45. doi: 10.1111/joim.12033. Epub 2013 Feb 10. Review. PubMed PMID: 23331408.

Martini S, Bernoth K, Main H, Ortega GD, Lendahl U, Just U, Schwanbeck R. A critical role for Sox9 in notch-induced astrogliogenesis and stem cell maintenance. Stem Cells. 2013 Apr;31(4):741-51. doi: 10.1002/stem.1320. PubMed PMID: 23307615.

2012

Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J. Alzheimer’s disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. J Neurosci. 2012 Nov 28;32(48):17297-305. doi:10.1523/JNEUROSCI.1451-12.2012. PubMed PMID: 23197721.

Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U. Non canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ. Oncogene. 2013 Oct 10;32(41):4892-902. doi: 10.1038/onc.2012.517. Epub 2012 Nov 26. PubMed PMID: 23178494; PubMed Central PMCID: PMC3795477.

Zhao, J., Lendahl, U. and Nistér, M. (2012) Regulation of mitochondrial dynamics: convergence and divergences between yeast and vertebrates. Cellular and Molecular Life Sciences, Jul 18 (epub ahead of print).

Borgegård, H., Gustavsson, S., Nilsson, C., Parpal, S., Klintenberg, R., Berg, A.-L., Rosqvist, S., Serneels, L., Svensson, S., Olsson, F., Jin, S., Yan, H., Wanngren, J., Jureus, A., Ridderstad-Wollberg, Å., Wollberg, P., Stockling, K., Karlström, H., Malmberg, Å., Lund, J., Arvidsson, P.I., De Strooper, B., Lendahl, U.* and Lundkvist, J*. (2012) Alzheimer’s disease: Presenilin 2-spating g-sectetase inhibition is a tolerable Abeta peptide lowering strategy. J. Neuroscience (in press) *Corresponding authors.

Jin, S., Mutvei, A.P., Chivukula, I., Andersson, E.R., Ramsköld, D., Sandberg, R., Lee, K.L., Kronqvist, P., Mamaeva, V. Screpanti, I., Poellinger, L., Sahlgren, C. and Lendahl, U. (2012) Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKalpha/IKKbeta. Oncogene (in press).

2011

Liu L, Lanner F, Lendahl U, Das D. Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling. Biochem Biophys Res Commun. 2011 Sep 30;413(3):426-31. Epub 2011 Aug 27. PubMed PMID: 21893032.

Landor SK, Mutvei AP, Mamaeva V, Jin S, Busk M, Borra R, Grönroos TJ, Kronqvist P, Lendahl U, Sahlgren CM. Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18814-9. Epub 2011 Nov 7. PubMed PMID: 22065781; PubMed Central PMCID: PMC3219154.

Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development. 2011 Sep;138(17):3593-612. Review. PubMed PMID: 21828089.

Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, Tomilin N, Shupliakov O, Lendahl U, Nistér M. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J. 2011 Jun 24;30(14):2762-78. doi: 10.1038/emboj.2011.198. PubMed PMID: 21701560; PubMed Central PMCID: PMC3160255.

2010

Larsson JK, Wadströmer N, Hermanson O, Lendahl U, Forchheimer R. Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks. J Theor Biol. 2011 Jan 7;268(1):62-76. Epub 2010 Oct 12. PubMed PMID: 20946901.

Das D, Lanner F, Main H, Andersson ER, Bergmann O, Sahlgren C, Heldring N, Hermanson O, Hansson EM, Lendahl U. Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells. Dev Biol. 2010 Dec 15;348(2):153-66. Epub 2010 Sep 29. PubMed PMID: 20887720.

Hansson EM, Lanner F, Das D, Mutvei A, Marklund U, Ericson J, Farnebo F, Stumm G, Stenmark H, Andersson ER, Lendahl U. Control of Notch-ligand endocytosis by ligand-receptor interaction. J Cell Sci. 2010 Sep 1;123(Pt 17):2931-42. PubMed PMID: 20720151.

Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U. Evidence for dimeric BACE-mediated APP processing. Biochem Biophys Res Commun. 2010 Feb 26;393(1):21-7. Epub 2010 Jan 25. PubMed PMID: 20097169.

Marklund U, Hansson EM, Sundström E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J. Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45. PubMed PMID: 20081190.

2009

Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet. 2009 Dec;10(12):821-32. Epub 2009 Nov 3. Review. PubMed PMID: 19884889.

Main H, Lee KL, Yang H, Haapa-Paananen S, Edgren H, Jin S, Sahlgren C,
Kallioniemi O, Poellinger L, Lim B, Lendahl U. Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells. Exp Cell Res. 2010 May 15;316(9):1610-24. Epub 2009 Dec 23. PubMed PMID: 20034489.

Andersson ER, Lendahl U. Regenerative medicine: a 2009 overview. J Intern Med. 2009 Oct;266(4):303-10. PubMed PMID: 19765176.

Rauen T, Raffetseder U, Frye BC, Djudjaj S, Mühlenberg PJ, Eitner F, Lendahl U, Bernhagen J, Dooley S, Mertens PR. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. J Biol Chem. 2009 Sep 25;284(39):26928-40. Epub 2009 Jul 29. PubMed PMID: 19640841; PubMed Central PMCID: PMC2785380.

2008

Poellinger L, Lendahl U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr Opin Genet Dev. 2008 Oct;18(5):449-54. Epub 2008 Sep 4. Review. PubMed PMID: 18722525.

Andäng M, Lendahl U. Ion fluxes and neurotransmitters signaling in neural development. Curr Opin Neurobiol. 2008 Jun;18(3):232-6. Review. PubMed PMID: 18638551.

Rizzo P, Miao H, D’Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 2008 Jul 1;68(13):5226-35. Erratum in: Cancer Res. 2008 Sep 1;68(17):7246. Song, Lynda L [added]. PubMed PMID: 18593923.

Lendahl U. [Dedifferentiation of specialized cells. New way open for cell therapy and regenerative medicine]. Lakartidningen. 2008 May 14-20;105(20):1492-4. Review. Swedish. PubMed PMID: 18575405.

Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L. Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells. Oncogene. 2008 Oct 2;27(44):5833-44. Epub 2008 Jun 16. PubMed PMID: 18560356.

Jin S, Hansson EM, Tikka S, Lanner F, Sahlgren C, Farnebo F, Baumann M, Kalimo H, Lendahl U. Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ Res. 2008 Jun 20;102(12):1483-91. Epub 2008 May 15. PubMed PMID: 18483410.

Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6392-7. Epub 2008 Apr 21. PubMed PMID: 18427106; PubMed Central PMCID: PMC2359811.

Holmberg J, Hansson E, Malewicz M, Sandberg M, Perlmann T, Lendahl U, Muhr J.SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation. Development. 2008 May;135(10):1843-51. Epub 2008 Apr 16. PubMed PMID: 18417619.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73. Epub 2008 Feb 25. PubMed PMID: 18299578; PubMed Central PMCID: PMC2265116.

2007

Ruas JL, Lendahl U, Poellinger L. Modulation of vascular gene expression by hypoxia. Curr Opin Lipidol. 2007 Oct;18(5):508-14. Review. PubMed PMID: 17885420.

Malyukova A, Dohda T, von der Lehr N, Akhoondi S, Corcoran M, Heyman M, Spruck C, Grandér D, Lendahl U, Sangfelt O. The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res. 2007 Jun 15;67(12):5611-6. Erratum in: Cancer Res. 2008 Mar 15;68(6):2051. Akhondi, Shahab [corrected to Akhoondi, Shahab]. PubMed PMID: 17575125.

Dohda T, Maljukova A, Liu L, Heyman M, Grandér D, Brodin D, Sangfelt O,Lendahl U. Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. Exp Cell Res. 2007 Aug 15;313(14):3141-52. Epub 2007 May 5. PubMed PMID: 17560996.

2006

Sahlgren C, Lendahl U. Notch signaling and its integration with other signaling mechanisms. Regen Med. 2006 Mar;1(2):195-205. Review. PubMed PMID: 17465803.

Chapman G, Liu L, Sahlgren C, Dahlqvist C, Lendahl U. High levels of Notch signaling down-regulate Numb and Numblike. J Cell Biol. 2006 Nov 20;175(4):535-40. PubMed PMID: 17116748; PubMed Central PMCID: PMC2064589.

Hansson EM, Teixeira AI, Gustafsson MV, Dohda T, Chapman G, Meletis K, Muhr J, Lendahl U. Recording Notch signaling in real time. Dev Neurosci. 2006;28(1-2):118-27. PubMed PMID: 16508309.

2005

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005 Nov;9(5):617-28. PubMed PMID: 16256737.